A study published in the latest edition of the European Heart Journal has found that individuals aged over 50 with systolic blood pressure over 130 mmHg had a increased risk- they were one and a half times more likely to develop dementia- than peers with ‘ideal’ blood pressure.
To examine associations of diastolic and systolic blood pressure (SBP) at age 50, 60, and 70 years with incidence of dementia, and whether cardiovascular disease (CVD) over the follow-up mediates this association.
Methods and results
Systolic and diastolic blood pressure were measured on 8639 persons (32.5% women) from the Whitehall II cohort study in 1985, 1991, 1997, and 2003. Incidence of dementia (n dementia/n total = 385/8639) was ascertained from electronic health records followed-up until 2017. Cubic splines using continuous blood pressure measures suggested SBP ≥130 mmHg at age 50 but not at age 60 or 70 was associated with increased risk of dementia, confirmed in Cox regression analyses adjusted for sociodemographic factors, health behaviours, and time varying chronic conditions. Diastolic blood pressure was not associated with dementia. Participants with longer exposure to hypertension (SBP ≥ 130 mmHg) between mean ages of 45 and 61 years had an increased risk of dementia compared to those with no or low exposure to hypertension. In multi-state models, SBP ≥ 130 mmHg at 50 years of age was associated with greater risk of dementia in those free of CVD over the follow-up.
Systolic blood pressure ≥130 mmHg at age 50, below the conventional ≥140 mmHg threshold used to define hypertension, is associated with increased risk of dementia; in these persons this excess risk is independent of CVD.
The full article is available to read at European Heart Journal
Abell, J.G., et al | 2018| Association between systolic blood pressure and dementia in the Whitehall II cohort study: role of age, duration, and threshold used to define hypertension | European Heart Journal ehy288| https://doi.org/10.1093/eurheartj/ehy288
OnMedica Blood pressure below treatable threshold linked to heightened dementia risk
In the media:
BBC News Unfit in middle age:Are you doomed?
A tailored lighting intervention in nursing homes can positively impact sleep, mood and behavior for patients with Alzheimer’s disease, according to preliminary findings from a new study | American Academy of Sleep Medicine | via ScienceDaily
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Full story at ScienceDaily
Further detail: American Academy of Sleep Medicine
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March 2018 Data (Quarter 4 2017-18) (released 6th June 2018)
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Full report: Hutchings, R. Carter, D.& Bennett, K. | Dementia – the true cost: fixing the care crisis | Alzheimer’s Society | May 2018
See also: Dementia patients ‘abandoned’ by system | BBC