Marriage may lower the risk of developing dementia

Marriage may help stave off dementia, study finds | Journal of Neurology Neurosurgery & Psychiatry


Researchers combining the results of 15 studies including data on more than 800,000 participants have found  that lifelong singletons and widowers appear to have a heightened risk of developing dementia.

Analysis of the data showed that lifelong singletons were 42% more likely to develop dementia than those who were married, and widowers were 20% more likely to develop the condition. Part of this risk might be explained by poorer physical health among lifelong single people, suggest the researchers.  Marriage may help both partners to have healthier lifestyles, including exercising more, eating a healthy diet, and smoking and drinking less, all of which have been associated with lower risk of dementia. Couples may also have more opportunities for social engagement than single people – a factor that has been linked to better health and lower dementia risk, the researchers suggest.

Full reference: Sommerlad A, et al. | Marriage and risk of dementia: systematic review and meta-analysis of observational studies |  Journal of Neurology Neurosurgery & Psychiatry | published online 28 November 2017

High-intensity exercise boosts memory, new research suggests

Heisz, J. et al. The Effects of Physical Exercise and Cognitive Training on Memory and Neurotrophic Factors. Journal of Cognitive Neuroscience, 2017; 29 (11) | story via ScienceDaily


The health advantages of high-intensity exercise are widely known but new research from McMaster University points to another major benefit: better memory.

The findings could have implications for an aging population which is grappling with the growing problem of catastrophic diseases such as dementia and Alzheimer’s.

Scientists have found that six weeks of intense exercise — short bouts of interval training over the course of 20 minutes — showed significant improvements in what is known as high-interference memory, which, for example, allows us to distinguish our car from another of the same make and model.

The findings are important because memory performance of the study participants, who were all healthy young adults, increased over a relatively short period of time, say researchers.

The study is published in the Journal of Cognitive Neuroscience

Full story at ScienceDaily


Public Health Interventions for Decreasing Dementia Risk

Hankey, G. J.  | Public Health Interventions for Decreasing Dementia Risk | JAMA Neurol. Published online November 20, 2017. doi:10.1001

Dementia is projected to be the greatest global challenge for health and social care this century. Dementia is a neurocognitive syndrome specific to people with otherwise normal brain development, characterized by a decline in level of cognitive ability that compromises social functioning or activities of daily living. At present, it affects nearly 50 million people globally; the increasing life expectancy of the global population means dementia threatens to affect 75 million people by 2030 and 132 million by 2050, unless effective prevention strategies can be identified and implemented. Its impact on affected individuals, families, and caregivers, as well as the community and economy, is already substantial because of the lack of effective, disease course-modifying treatment.

This paper describes the current public health burden of dementia and the recent insights and ongoing research needs for effective, appropriate prevention.

Further detail at JAMA Network

New research shows where in the brain the earliest signs of Alzheimer’s occur

Researchers have convincingly shown where in the brain the earliest signs of Alzheimer’s occur.  Nature Communications | Story via ScienceDaily

In Alzheimer’s, the initial changes in the brain occur through retention of the protein, ?-amyloid (beta-amyloid). The process begins 10-20 years before the first symptoms become noticeable in the patient.

In Nature Communications, a research team has presented results showing where in the brain the initial accumulation of ?-amyloid occurs.  It is hoped that the discovery could potentially become significant to future Alzheimer’s research while contributing to improved diagnostics.

Full story at ScienceDaily

Link to the research: Palmqvist, S et al. Earliest accumulation of β-amyloid occurs within the default-mode network and concurrently affects brain connectivity. Nature Communications, 2017; 8 (1)

Home support services in later stage dementia

Kampanellou, E at al. | Carer preferences for home support services in later stage dementia  | Aging and Mental Health | Published online: 01 Nov 2017

Objectives: To examine the relative importance of different home support attributes from the perspective of carers of people with later-stage dementia.

Method: Preferences from 100 carers, recruited through carers’ organisations, were assessed with a Discrete Choice Experiment (DCE) survey, administered online and by paper questionnaire. Attributes were informed by an evidence synthesis and lay consultations. A conditional logit model was used to estimate preference weights for the attributes within a home support ‘package’.

Results: The most preferred attributes were ‘respite care, available regularly to fit your needs’ (coefficient 1.29, p = < 0.001) and ‘home care provided regularly for as long as needed’ (coefficient 0.93, p = < 0.001). Cost had a significant effect with lower cost packages preferred. Findings were similar regardless of the method of administration, with respite care considered to be the most important attribute for all carers. Carers reported that completing the DCE had been a positive experience; however, feedback was mixed overall.

Conclusions: These carer preferences concur with emerging evidence on home support interventions for dementia. Respite care, home care and training on managing difficulties provided at home are important components. Carers’ preferences revealed the daily challenges of caring for individuals with later stage dementia and the need for tailored and specialised home support.


Risk factors & Alzheimers Disease: Sleep disturbance, depression and anxiety

Findings suggest that sleep disturbance, depression, and anxiety are associated with AD development among cognitively asymptomatic participants | Aging & Mental Health


Objectives: Alzheimer’s disease (AD) dementia is a neurodegenerative condition, which leads to impairments in memory. This study predicted that sleep disturbance, depression, and anxiety increase the hazard of AD, independently and as comorbid conditions.

Methods: Data from the National Alzheimer’s Coordinating Center was used to analyze evaluations of 12,083 cognitively asymptomatic participants. Survival analysis was used to explore the longitudinal effect of depression, sleep disturbance, and anxiety as predictors of AD. The comorbid risk posed by depression in the last two years coupled with sleep disturbance, lifetime depression and sleep disturbance, clinician-verified depression and sleep disturbance, sleep disturbance and anxiety, depression in the last two years and anxiety, lifetime depression and anxiety, and clinician-verified depression and anxiety were also analyzed as predictors of AD through main effects and additive models.

Results: Main effects models demonstrated a strong hazard of AD development for those reporting depression, sleep disturbance, and anxiety as independent symptoms. The additive effect remained significant among comorbid presentations.

Conclusion: Findings suggest that sleep disturbance, depression, and anxiety are associated with AD development among cognitively asymptomatic participants. Decreasing the threat posed by psychological symptoms may be one avenue for possibly delaying onset of AD.

Full reference: Shanna L. Burke et al. |  Psychosocial risk factors and Alzheimer’s disease: the associative effect of depression, sleep disturbance, and anxiety  | Aging & Mental Health | Published online: 27th Oct 2017