The effects of vitamin and mineral supplementation on cognitive function and the incidence of dementia in people with mild cognitive impairment.

This review investigated whether people with mild cognitive impairment can reduce their risk of developing dementia, or can prevent their memory or other thinking skills from deteriorating further, by taking vitamin or mineral supplements | Cochrane Database of Systematic Reviews

Vitamins and minerals have many functions in the nervous system which are important for brain health. It has been suggested that various different vitamin and mineral supplements might be useful in maintaining cognitive function and delaying the onset of dementia. In this review, the authors sought to examine the evidence for this in people who already had mild cognitive impairment (MCI).

The authors found eight randomised controlled trials (RCTs), which investigated four different types of vitamin or mineral pills by comparing them to a placebo (a dummy pill). The vitamins tested were B vitamins (vitamin B6, vitamin B12 and folic acid), vitamin E, and vitamin E and C given together. The only mineral tested was chromium.

However, the authors found the amount and quality of research evidence about vitamin and mineral supplements for treating MCI in people without nutritional deficiency is limited. They concluded that at the moment, it is not possible to identify any supplements which can reduce the risk of people with MCI developing dementia or which can effectively treat their symptoms.

Full reference: McCleery J, et al. |  Vitamin and mineral supplementation for preventing dementia or delaying cognitive decline in people with mild cognitive impairment |  Cochrane Database of Systematic Reviews | 2018, Issue 11.

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