Stroke and dementia risk: A systematic review and meta-analysis

Kuźma, Elżbieta et al.| 2018| Stroke and dementia risk: A systematic review and meta-analysis| Alzheimer’s & Dementia: The Journal of the Alzheimer’s Association , Vol. 0 , Issue 0 | https://doi.org/10.1016/j.jalz.2018.06.3061

A new systematic review and meta- analysis is the first to conduct a meta-analysis of the relationship between stroke and all-cause dementia risk. This systematic review and meta-analysis provides evidence that stroke is a strong independent risk factor for dementia. The review is published in Alzheimer & Dementia: The Journal of the Alzheimer’s Association.

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Abstract

Introduction

Stroke is an established risk factor for all-cause dementia, though meta-analyses are needed to quantify this risk.

Methods

We searched Medline, PsycINFO, and Embase for studies assessing prevalent or incident stroke versus a no-stroke comparison group and the risk of all-cause dementia. Random effects meta-analysis was used to pool adjusted estimates across studies, and meta-regression was used to investigate potential effect modifiers.

Results

We identified 36 studies of prevalent stroke (1.9 million participants) and 12 studies of incident stroke (1.3 million participants). For prevalent stroke, the pooled hazard ratio for all-cause dementia was 1.69. Study characteristics did not modify these associations, with the exception of sex which explained 50.2% of between-study heterogeneity for prevalent stroke.

Discussion

Stroke is a strong, independent, and potentially modifiable risk factor for all-cause dementia.

Read the full article at the Alzheimer’s & Dementia

 

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