Jia, J. et al. Alzheimers & Dementia. Published online: 23 February 2017
Introduction: Rapid cognitive decline (RCD) occurs in dementia due to Alzheimer’s disease (AD).
Discussion: RCD is sufficiently common to interfere with randomized clinical trials. We propose a 6-month prerandomization determination of the decline rate or use of an RCD risk score to ensure balanced allocation among treatment groups.
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